D824 - Hyperimmunoglobulin E (IgE) syndrome - a rare genetic immune system disorder causing very high IgE antibody levels

International Classification of Diseases

Last updated: 10/3/2025

What is a ICD-10 Code?

ICD-10 (International Classification of Diseases, 10th Revision) codes are used to classify and code all diagnoses, symptoms, and procedures recorded in association with hospital care. These codes provide a standardized way to track health conditions and their treatment outcomes.

Detailed Description

Hyperimmunoglobulin E (IgE) syndrome, also known as Job syndrome, is a rare inherited immune system disorder. People with this condition have extremely high levels of IgE antibodies in their blood - much higher than normal. IgE antibodies are part of your immune system that typically help fight parasites and are involved in allergic reactions. This syndrome causes recurring skin infections, lung infections, and distinctive facial features. Patients often experience severe eczema-like skin rashes, frequent bacterial infections (especially staph infections), and may have problems with their bones, teeth, and connective tissues. The condition is present from birth but symptoms may not appear until childhood or later. It requires ongoing medical management to prevent and treat infections.

Additional Information

This is a lifelong genetic condition requiring specialized care from multiple medical specialists. Early diagnosis and treatment can significantly improve quality of life and prevent serious complications.

Category

Immunological Disorders

Medical Specialty

Immunology/Allergy, Dermatology, Infectious Disease

Expected Costs

Your actual cost will depend on your insurance coverage, provider location, and specific circumstances.

What's Required Before This

  • Genetic testing may be recommended
  • Family history evaluation
  • Comprehensive immune system testing

What to Expect After

  • Regular monitoring by immunologist
  • Preventive antibiotic therapy
  • Skin care management
  • Infection surveillance
  • Possible immunoglobulin replacement therapy

Why Understanding This Code Matters

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For Your Health

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